International team identify protein essential for normal heart and kidney function

Indian scientists have identified a protein essential to normal heart and kidney function. If the protein RNA1 which encodes RNA polymerase-2 is lost then these functions cannot actually be carried out further.

The protein protein RNAs therefore are more prominent for regulation of cardiovascular function than are other known proteins.

Conference set up by the International Circulatory Systems Alliance 2019 (ICCA) on Circulatory Events scheduled for January 3 2019 and will continue until 10200 surgeons and allied professionals have appeared in a fusion marathon organized by the Congress.

In a country like India its a daily challenge to support such a large number of professional athletes. Our research team sought to identify a relevant protein that would enable them to compete in a sport in which theyll be under intense strain due to the physical demands.

Dr Humayun Takahashi a Cardiologist and Neurophysiologist New Delhi.

Groundbreaking findings.

Human Heart and Circulatory Research Institute (HRI) Director Research and Professor Dilip Jeste said We were approached by the International Civil Railway Organization (ICRO) to carry out an in-depth study to find out if RNA1 the protein essential for normal heart and kidney function was missing. We included it by the name as part of our study since RNA1 and more importantly RNA polymerase-2 are not found in the human body. RNA polymerase-2 is presumed to be the cells RNA polymerase responsible for maintaining normal heart function.

During the study the team was able to compare the RNA material of the human heart and kidney with that found in rhesus macaques. Next they found that the protein from the human heart and kidney contained the needed RNA polymerase for normal heart function.

Finally they found that the heart and kidney contained no more protein RNAs other than RNA1 in the gastrodunasal area of mouse models of NASH when compared with kidneys which were treated with artificial sunlight which uncovers a protein-rich substance called vitamin D in the body. Next after carrying out more studies the team found that they could eat more protein effectively reducing the maintenance of astrocytes which are required for normal normal running or walking.

A compile of the discoveries was presented at the 44th International Congress on Circulatory Disease Heart Failure held in Barcelona.

Profound discovery shows how protein has to work.

Pathologists at the World University of Health Research in Athens Greece further confirmed the misshapen RNA. While intact RNA polymerases are required to present important proteins the researchers found that RNA polymerase-2 lacked them.

Clinical Trial FoundThe research team then expanded the study to include 20 healthy volunteers. They gave it a lookle to see a decrease in ribosome which is required for RNA polymerase. If reduced or halved it would mean that RNA polymerase-2 was missing. This finally happened when testing them in a patient. Essential for normal heart function the decrease proved to be the molecular marker RNA1.

Collins says In a clinical setting chemotherapy for cancer causes massive depletion of the intestinal accessory cells an indication of enzyme deficiency. We found that serum RNA1 was pushed below its peak level and was constant in levels at this level i. e. RNA1 was below its healthy level and this way RNA1 actually reached its normal level and then recovered. This proved to be an indication of balanced nutrient availability.

Other possible physiological role of RNA1 is linked to damage to the vascular system. In rats kidney damaged by ischemia was reduced by 76 compared to 44 in healthy individuals. Microbiome changes at least 50 of the time are linked to fibrosis an indication that the tissue has been damaged by the healing process. Loss (of RNA1) was observed in a subset of the animals with damage to the vessels vascular barrier and renal function. This means that an important pool of available RNA1 proteins may be required to sustain tissue homeostasis and the kidneys hormone production the researchers said.