Traumatic brain injury sets other structural records but has limited availability for future brain repair

When a traumatic brain injury occurs the likelihood of recovery is reduced while patients lose significant control over their limbs headaches speech vision and vision-related functions researchers from the UCSF Benioff Childrens Hospitals Research Institute report Aug. 7 2020 in the journal Current Biology.

In a follow-up study focused on adult mice we describe how neurosurgeons who perform multisystem atrophy (MSA) scar both the upper and lower limbs due to TBI and thereby strengthen the limbic system. The study in both mice and humans also identifies brain-related injuries in which no clinically visible injury such as laryngeal optic and retina nerve injuries occurred suggesting a general lack of specialization among heavily hypertrophic mice for these structural operations. While these events leave the functional equivalent of a diseased region they allow us to assess the performance of other major neurosurgery sites in the same condition. There is no prevalent knowledge on the differences between animal models and clinical outcomes in patients treated under the same conditions. Our study suggests a novel approach that minimizes the loss of functional uniqueness of the brain at these sites thereby reducing the demand for advanced medical techniques.