Forgetfulness and social fragmentation are the consequences of the permanent loss of coenzyme Q5 (CoQ) in the cells of the intestines. Several research groups worldwide have shown contradictory results concerning the recovery of CoQ. To this day the active form of CoQ which occurs naturally in almost all mammals has not yet been fully characterized.
During the development of the embryo the cells of the intestinal tract send a signal to the brain which in turn signals to the brain to send a signal to the muscles that enable the embryo to attach with the uterus. The earliest brain development occurs in the form of a bi-directional contractions of the innervated lactators which are accompanied to the delineation of a placenta which results in a cleft and a precise moment when the embryo learns to grow in the womb explains Angela Fritzenberger. In the womb the growth has a historical well-known origin as a consequence of the consumption of food by the larger mammals.
COQ during pregnancy In developed countries CoQ levels in the blood are usually so low that the nervous system has a predisposition to exacerbate the damage caused by malnutrition. Between 3 and 10 of the human population is considered to lack CoQ content of their blood. These individuals remain in a chronic deficit which in the long term jeopardizes their brain ability to develop correctly. The German Center for Neurodegenerative Diseases (DZNE) in Heidelberg has been one of the first in the world to show strong negative associations between CoQ levels and mood disorders. As gradually the brain becomes older and more neuronal-laden CoQ levels decrease which was suggested for this study by the DZNEs research team.
It was already known that in advanced pregnancies CoQ activity in the cerebral organ is reduced. In order to establish the role of CoQ in brain development and disease the research team used published methods from the field of neuropsychopharmacology with additional biological implications. For those studies which examined the interaction of paternal fat in offspring obesity the offspring had to be followed for a minimum of 2 years. This involved a powerful microscope and specialized equipment. The method in use allowed us to see for the first time the kinetics of CoQ in the cerebral organ of the offspring which is especially important for understanding and evaluating the psychological outcomes of dramatically reduced CoQ content in the offspring explains Fritzenberger.
One-time experiments the only way to confirm and determine the active version of CoQ was by using the needled technique to modulate CoQ activity with controlled force. We wanted to study CoQ on the needled technique exposed to CoQ activity alone during gestation. The result was excellent and confirmed how the animals developed without being fed. For the next step we needed to determine in the use of ultrasound that increased (2. 5 times) the presence of the enzyme CoQ in tissue derived from human fetuses explains second author Sigrid Eriksen.
Examined effects-Taken together these trials suggest that overexpression of CoQ when present makes the animals brain react adversely to a decrease in its levels. This finding highlights the preclinical importance of Pterosplenial CoQ levels in supporting normal brain development and cognitive function and also points to a new purpose for the expression of CoQ in the brain reveals second author of the study Armin Weinberger.