A step closer to understanding a pathologically important enzyme that is otherwise unclear to researchers and scientists physiologist Jonas-Eric Vterhazy told Agence France-Presse the week of 11-13 October 2020.
This micronucleus seen in microsatellite fragments of cancer cells may be an important albeit involved regulatory factor in various disease processes he said.
The micronucleus is part of the essential biosystem called the MSC and especially the amount of carbohydrates in the cells determines its ability to respond to nutritional stress. Under certain circumstances the process of adapting to nutritional stress or of changing the function of cell adrenergic neurons becomes insufficient. Because of this disruption tissues members of the MSC can develop abnormally high metabolic demands and thus cancer. The invaginations of cancer cells in early development reveal a mysterious micronucleus.
Another long-standing problem researchers face in their attempts to understand the micronucleus is its crucial role in maintaining immune cells which is needed to fight infection and cancer.
In this manuscript Jonas Eric Vterhazy addressed the question of how a micronucleus contributes to immune cells and by how it behaves in vivo. Recent studies suggest that a high-fructose sweetener sometimes called sucralfate may be the origins of the micronucleus.
In the microsatellite fragment that is better understood the number of sugars and carbohydrates in the cell can vary and the cells ability to respond to diet is reduced. The metabolism of this complex system is also probably not fully understood.
In response to nutritional stress the micronucleus shows dysregulated expression of microRNAs genes that alter the target genes which could explain at least in part the observed associations with cancers and most likely other immune pathologies such as asthma or inflammatory bowel disease which prompted this new consensus statement says Jonas Eric Vterhazy.
This finding could also help researchers better understand mechanisms underlying the relationship between microRNAs and cancer.
We know its a novel process but this one we dont have much information on he explains.
He points to what the researchers already know – that micronuclei are important regulators of the cells metabolic response to dietary sugars but what really happens when they understand more about them: What really happens in cancer cells? I think we need to take a closer look at the communication between the microarray and the micronucleus during this process.